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darkoz
darkoz
Joined: Dec 22, 2009
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May 23rd, 2020 at 12:31:44 PM permalink
Bad news

Remdesvir has turned out to be a dud!

Of course millions were ordered while Gilead stock rose astronomically on their "leaked" info.

Full clinical results have now been released

The leaked results were a cherry picked aspect of a small portion. (Section redacted)

Read this sad article. Gets to the point quickly

https://www.zerohedge.com/technology/remdesivir-study-finally-out-drug-only-helped-those-oxygen-finds-mortality-too-high

And here is the study graph. Highlighted is the cherry picked section. Read across the line "deaths at day 14"

Last edited by: darkoz on May 23, 2020
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Venthus
Venthus
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May 23rd, 2020 at 12:51:20 PM permalink
Quote: darkoz

Adding insult to injury more people died on Remdesvir than on the placebo.



What part made or implied that claim? Unless I'm grossly misreading the article and table, what I'm seeing is that less people died while on Remdesivir over all, but its significance is questionable, from both a statistical and absolute value. The vast majority of its benefit is only in a very specific set of cases.

The linked article itself states "Finally, the study found that while mortality was modestly lower for the remdesivir arm, it was not significantly so, at 7.1% at 14 days on drug versus 11.9% on placebo."


Edit: Resolved.
billryan
billryan
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May 23rd, 2020 at 12:56:45 PM permalink
Everyone in the news, who have not invested heavily in some other drug, reads that study as a good thing. The only problem is getting to a scale where millions of doses will be readily available.
rxwine
rxwine
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May 23rd, 2020 at 12:58:48 PM permalink
As an aside, I do hope they severely punish any company pushing exaggerated claims that has shown to profit from it.
Quasimodo? Does that name ring a bell?
darkoz
darkoz
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May 23rd, 2020 at 1:01:09 PM permalink
Quote: Venthus

What part made or implied that claim? Unless I'm grossly misreading the article and table, what I'm seeing is that less people died while on Remdesivir over all, but its significance is questionable, from both a statistical and absolute value. The vast majority of its benefit is only in a very specific set of cases.

The linked article itself states "Finally, the study found that while mortality was modestly lower for the remdesivir arm, it was not significantly so, at 7.1% at 14 days on drug versus 11.9% on placebo."



Yeah I think I misread the chart

I'm retracting that from the original post

Still the article doesn't look good for Remdesvir
For Whom the bus tolls; The bus tolls for thee
billryan
billryan
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May 23rd, 2020 at 1:09:15 PM permalink
71 deaths per thousand vs 119 per thousand. That's close to a 50% drop in deaths. I don't see anything modest in that.
ChumpChange
ChumpChange 
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May 23rd, 2020 at 1:10:56 PM permalink
Didn't the Dow jump 1000 points on this fake news early this week?
darkoz
darkoz
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May 23rd, 2020 at 1:12:01 PM permalink
Quote: billryan

71 deaths per thousand vs 119 per thousand. That's close to a 50% drop in deaths. I don't see anything modest in that.



I'm going by medical articles because I am not a medically trained person.

The below article also states the survival rate Remdesvir vs. placebo is not looking good

https://www.biopharmadive.com/news/gilead-remdesivir-nejm-nih-results/578545/
For Whom the bus tolls; The bus tolls for thee
coilman
coilman
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Venthus
Venthus
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May 23rd, 2020 at 1:28:08 PM permalink
I think the more useful read of this report (in terms of life saving) would be that for the people who are in the category of "hospitalized, requiring any supplemental oxygen", the treatment can be tentatively considered to be highly effective-- a drop in mortality rates from ~11% to ~2.5%.

For everybody else... probably not worth it (barring possibly T7). So: Good job, there's a viable treatment for a specific circumstance, keep plugging away at more and better options that don't have such a limited window of effectiveness.

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